log4net仪表板上的该线程详细介绍了一种方法。

总结一下，希望不要剥离太多代码：

using log4net;
using log4net.Appender;
using log4net.Layout;
using log4net.Repository.Hierarchy;

// Set the level for a named logger
public static void SetLevel(string loggerName, string levelName)
{
    ILog log = LogManager.GetLogger(loggerName);
    Logger l = (Logger)log.Logger;

    l.Level = l.Hierarchy.LevelMap[levelName];
    }

// Add an appender to a logger
public static void AddAppender(string loggerName, IAppender appender)
{
    ILog log = LogManager.GetLogger(loggerName);
    Logger l = (Logger)log.Logger;

    l.AddAppender(appender);
}

// Create a new file appender
public static IAppender CreateFileAppender(string name, string fileName)
{
    FileAppender appender = new
        FileAppender();
    appender.Name = name;
    appender.File = fileName;
    appender.AppendToFile = true;

    PatternLayout layout = new PatternLayout();
    layout.ConversionPattern = "%d [%t] %-5p %c [%x] - %m%n";
    layout.ActivateOptions();

    appender.Layout = layout;
    appender.ActivateOptions();

    return appender;
}

// In order to set the level for a logger and add an appender reference you
// can then use the following calls:
SetLevel("Log4net.MainForm", "ALL");
AddAppender("Log4net.MainForm", CreateFileAppender("appenderName", "fileName.log"));

// repeat as desired