像这样？

public static void Test()
{
    using (var image = Image.FromFile(@"c:\logo.png"))
    using (var newImage = ScaleImage(image, 300, 400))
    {
        newImage.Save(@"c:\test.png", ImageFormat.Png);
    }
}

public static Image ScaleImage(Image image, int maxWidth, int maxHeight)
{
    var ratioX = (double)maxWidth / image.Width;
    var ratioY = (double)maxHeight / image.Height;
    var ratio = Math.Min(ratioX, ratioY);

    var newWidth = (int)(image.Width * ratio);
    var newHeight = (int)(image.Height * ratio);

    var newImage = new Bitmap(newWidth, newHeight);

    using (var graphics = Graphics.FromImage(newImage))
        graphics.DrawImage(image, 0, 0, newWidth, newHeight);

    return newImage;
}