我找到了一种方法（不知道这是否是最好的方法，但它确实有效）

string oldFile = "oldFile.pdf";
string newFile = "newFile.pdf";

// open the reader
PdfReader reader = new PdfReader(oldFile);
Rectangle size = reader.GetPageSizeWithRotation(1);
Document document = new Document(size);

// open the writer
FileStream fs = new FileStream(newFile, FileMode.Create, FileAccess.Write);
PdfWriter writer = PdfWriter.GetInstance(document, fs);
document.Open();

// the pdf content
PdfContentByte cb = writer.DirectContent;

// select the font properties
BaseFont bf = BaseFont.CreateFont(BaseFont.HELVETICA, BaseFont.CP1252,BaseFont.NOT_EMBEDDED);
cb.SetColorFill(BaseColor.DARK_GRAY);
cb.SetFontAndSize(bf, 8);

// write the text in the pdf content
cb.BeginText();
string text = "Some random blablablabla...";
// put the alignment and coordinates here
cb.ShowTextAligned(1, text, 520, 640, 0);
cb.EndText();
cb.BeginText();
text = "Other random blabla...";
// put the alignment and coordinates here
cb.ShowTextAligned(2, text, 100, 200, 0);
cb.EndText();

// create the new page and add it to the pdf
PdfImportedPage page = writer.GetImportedPage(reader, 1);
cb.AddTemplate(page, 0, 0);

// close the streams and voilá the file should be changed :)
document.Close();
fs.Close();
writer.Close();
reader.Close();

我希望这对某人==有用（并在此处发布任何错误）