这是一个例子

static class Program
{
    [DllImport("user32.dll")]
    public static extern int SetForegroundWindow(IntPtr hWnd);

    [STAThread]
    static void Main()
    {
        while(true)
        {
            Process [] processes = Process.GetProcessesByName("iexplore");

            foreach(Process proc in processes)
            {
                SetForegroundWindow(proc.MainWindowHandle);
                SendKeys.SendWait("{F5}");
            }

            Thread.Sleep(5000);
        }
    }
}

更好的…更少的烦恼…

static class Program
{
    const UInt32 WM_KEYDOWN = 0x0100;
    const int VK_F5 = 0x74;

    [DllImport("user32.dll")]
    static extern bool PostMessage(IntPtr hWnd, UInt32 Msg, int wParam, int lParam);

    [STAThread]
    static void Main()
    {
        while(true)
        {
            Process [] processes = Process.GetProcessesByName("iexplore");

            foreach(Process proc in processes)
                PostMessage(proc.MainWindowHandle, WM_KEYDOWN, VK_F5, 0);

            Thread.Sleep(5000);
        }
    }
}