当然可以，只需一个小的启动脚本。从交互式输入编辑及历史替换在Python教程：

# Add auto-completion and a stored history file of commands to your Python
# interactive interpreter. Requires Python 2.0+, readline. Autocomplete is
# bound to the Esc key by default (you can change it - see readline docs).
#
# Store the file in ~/.pystartup, and set an environment variable to point
# to it:  "export PYTHONSTARTUP=~/.pystartup" in bash.

import atexit
import os
import readline
import rlcompleter

historyPath = os.path.expanduser("~/.pyhistory")

def save_history(historyPath=historyPath):
    import readline
    readline.write_history_file(historyPath)

if os.path.exists(historyPath):
    readline.read_history_file(historyPath)

atexit.register(save_history)
del os, atexit, readline, rlcompleter, save_history, historyPath

从Python
3.4开始，交互式解释器开箱即用地支持自动完成和历史记录：

现在，在支持的系统上的交互式解释器中，默认情况下启用了制表符完成功能readline。默认情况下，历史记录也处于启用状态，并且被写入文件（或从文件中读取）~/.python- history。