对于OSX 10.6用户，这是一个讨论很多的问题，但是我一直无法找到有效的解决方案。这是我的设置：

Python 2.6.1 64位Django 1.2.1 MySQL 5.1.47 osx10.6 64位

我使用–no-site-packages创建了一个virtualenvwrapper，然后安装了Django。当我激活virtualenv并运行python manage.py syncdb时，出现以下错误：

Traceback (most recent call last):
File "manage.py", line 11, in <module>
  execute_manager(settings)
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/core/management/__init__.py", line 438, in execute_manager
  utility.execute()
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/core/management/__init__.py", line 379, in execute
  self.fetch_command(subcommand).run_from_argv(self.argv)
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/core/management/__init__.py", line 257, in fetch_command
  klass = load_command_class(app_name, subcommand)
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/core/management/__init__.py", line 67, in load_command_class
  module = import_module('%s.management.commands.%s' % (app_name, name))
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/utils/importlib.py", line 35, in import_module
  __import__(name)
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/core/management/commands/syncdb.py", line 7, in <module>
from django.core.management.sql import custom_sql_for_model, emit_post_sync_signal
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/core/management/sql.py", line 5, in <module>
from django.contrib.contenttypes import generic
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/contrib/contenttypes/generic.py", line 6, in <module>
  from django.db import connection
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/db/__init__.py", line 75, in <module>
  connection = connections[DEFAULT_DB_ALIAS]
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/db/utils.py", line 91, in __getitem__
  backend = load_backend(db['ENGINE'])
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/db/utils.py", line 32, in load_backend
  return import_module('.base', backend_name)
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/utils/importlib.py", line 35, in import_module
  __import__(name)
File "/Users/joerobinson/.virtualenvs/dj_tut/lib/python2.6/site-packages/django/db/backends/mysql/base.py", line 14, in <module>
  raise ImproperlyConfigured("Error loading MySQLdb module: %s" % e)
django.core.exceptions.ImproperlyConfigured: Error loading MySQLdb module: No module named MySQLdb

我还安装了MySQL for Python适配器，但无济于事（也许我安装不正确？）。