我相信我已经找到了一个优雅的解决方案：

JavaScript

/* important! for alignment, you should make things
 * relative to the canvas' current width/height.
 */
function draw() {
  var ctx = (a canvas context);
  ctx.canvas.width  = window.innerWidth;
  ctx.canvas.height = window.innerHeight;
  //...drawing code...
}

CSS

html, body {
  width:  100%;
  height: 100%;
  margin: 0;
}

到目前为止，对我没有太大的负面性能影响。